منابع مشابه
Microbial hydroxylation of novobiocin and related compounds.
A new soil actinomycete (UC 5762, NRRL 11111) was found to transform novobiocin to 11-hydroxynovobiocin. The product was isolated by solvent extraction and column chromatography, and identified by IR, UV, 1H NMR and 13C NMR spectroscopy. Related structures (8,9-dihydronovobiocin, novobiocic acid and chlorobiocin) were similarly transformed to their corresponding C-11 hydroxylated analogues. The...
متن کاملContinuous fermentation of novobiocin.
Continuous fermentation trials with Streptomyces niveus in a nine-stage fermentation system (7-liter reaction volume per stage) indicated that the cultures used gradually lost their ability to produce novobiocin when cultured over periods from 10 to 25 days. It was found that mycelial degeneration could be circumvented by operational means during continuous culture using the following technique...
متن کاملMicrobial O-phosphorylation of macrolide antibiotics.
Crude enzymepreparations of Streptomyces coelicolor (Miiller), UC 5240 in the presence of ATP and Mg2+ catalyzed the conversion of oleandomycin, tylosin, leucomycin A3 and a mixture of spiramycins I, II and III to their antibiotically inactive I'-O-phosphates.10 Under identical conditions, erythromycin was converted to anhydroerythromycin-Z'-O-phosphate.10 As O-phosphorylation of aminocyclitols...
متن کاملProtein carbamylation is a hallmark of aging.
Aging is a progressive process determined by genetic and acquired factors. Among the latter are the chemical reactions referred to as nonenzymatic posttranslational modifications (NEPTMs), such as glycoxidation, which are responsible for protein molecular aging. Carbamylation is a more recently described NEPTM that is caused by the nonenzymatic binding of isocyanate derived from urea dissociati...
متن کاملProtein Carbamylation and Cardiovascular Disease
Carbamylation constitutes a posttranslational modification of proteins or amino acids and results from different pathways in vivo. First is the non-enzymatic reaction between isocyanic acid, a decomposition product of urea, and either the N-terminus or the ɛ-amino group of lysine residues. Isocyanic acid levels, while low in vivo, are in equilibrium with urea and are thus increased in chronic a...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1991
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.44.1096